Clinical Trial

NR vs. Vitamin E in Enhancing Fertility

Study acronym: NRVEERSAAM
Not Yet Recruiting
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Record status
This record was last updated April 30, 2025 (before its estimated April 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
This randomized controlled trial enrolled women of advanced maternal age (≥35 years) undergoing ART, who were allocated to an intervention group (oral nicotinamide riboside, NR) or a control group (oral vitamin E, VitE) for a 2-month pre-ART intervention. The study systematically evaluated NR's regulatory effects on ovarian function and ART outcomes by measuring NAD+ levels in ovarian granulosa cells (GCs) and peripheral blood mononuclear cells (PBMCs), anti-Müllerian hormone (AMH) concentrations.
Trial Details
NCT Number NCT06950736
Lead Sponsor The First Affiliated Hospital of Zhengzhou University
Conditions Infertility Female
Enrollment 60 participants
Start Date 2025-05-05
Primary Completion 2026-04-01 (estimated)
Study Completion 2027-12-01 (estimated)
Updated on ClinicalTrials.gov 2025-04-30