AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions

The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors. The study compares three groups: one performing aerobic cycling at an intensity that elevates lactate levels, one performing low-intensity exercise, and one receiving health education without exercise. All participants will complete motor learning tasks and undergo brain-stimulation testing using transcranial magnetic stimulation (TMS) to assess how well the brain responds to training. The goal is to understand whether different types of exercise can improve brain function, movement, and memory, and how the body's response to exercise (like lactate levels) might support brain health. This research may help identify low-cost, non-invasive interventions-such as targeted exercise-that improve motor and cognitive outcomes in aging and stroke recovery.

NCT Number	NCT06950060
Lead Sponsor	University of Alabama at Birmingham
Conditions	Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction, Neuroplasticity
Enrollment	48 participants
Start Date	2026-07-15
Primary Completion	2029-09-01 (estimated)
Study Completion	2030-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-17