Clinical Trial

Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal

Study acronym: ENDOA
Active, Not Recruiting
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Summary
The aim of the study is first, to evaluate the clinical antibacterial efficacy of two different NaOCl concentrations (2,5% and 5%) under a predefined irrigant flow rate in teeth with pulp necrosis and apical periodontitis by using Real-time PCR. . Second, to evaluate the efficacy of final irrigation by assessing, if possible, a numerical definition for that "so called" as "copious irrigation". Besides the total microbial load, the antibacterial efficacy of final irrigation procedure against two different bacterial species (namely Pseudoramibacter alactolyticus and Treponema denticola) will also be examined.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-04-28.
Trial Details
NCT Number NCT06949176
Lead Sponsor National and Kapodistrian University of Athens
Conditions Apical Periodontitis, Root Canal Infection
Enrollment 44 participants
Start Date 2023-12-01
Primary Completion 2024-12-12 (estimated)
Study Completion 2025-06-23 (estimated)
Updated on ClinicalTrials.gov 2025-05-11