Clinical Trial

A Study on Exploring the Abscopal Effect Induced by Different Radioimmunotherapy Combination Patterns in the Treatment of Non-Small Cell Lung Cancer With Multiple Metastases

Recruiting Phase 2
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Summary
It is planned to carry out a multicenter umbrella study to find the optimal organ combination and the best radioimmunotherapy combination pattern, so as to improve the survival of NSCLC patients with multiple metastases. At the same time, by using multimodal omics data, machine learning will be employed to construct a prediction model for the abscopal effect, and explore the immunoregulation of organ-specific radiotherapy and biomarkers of the abscopal effect. The main objective is to find the optimal organ combination and the best radioimmunotherapy combination pattern.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-04-20; most recent amendment 2025-07-16.
Status change: Not Yet Recruiting → Recruiting 2025-07-16
Trial Details
NCT Number NCT06947694
Lead Sponsor Xinqiao Hospital of Chongqing
Conditions NSCLC Stage IV Without EGFR/ALK Mutation
Enrollment 427 participants
Start Date 2025-07-02
Primary Completion 2026-12-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-07-22