Assessing the Time-Course of Dexmedetomidine-Induced Analgesia Via EEG

Objective: To investigate the temporal dynamics of dexmedetomidine's analgesic effects in the brain using EEG. Methods: Eligible patients scheduled for total hip arthroplasty under intrathecal anesthesia received a continuous infusion of DEX at 1.5 μg/(kg·h) for 15 minutes before neuraxial puncture, followed by an additional 15-minute infusion. The study was divided into three phases: Phase 1: Non-dosing phase (Baseline). Phase 2: DEX preemptive analgesia phase (DEX infusion). Phase 3: DEX cessation phase (Post-infusion). Outcomes: Primary safety outcome: EEG spectral analysis at different phases. Secondary outcomes: NRS scores, postoperative nausea and vomiting (PONV), dizziness, agitation, and time to intestinal exhaust within 48 hours. Intraoperative hemodynamics were also monitored.

NCT Number	NCT06946277
Lead Sponsor	China International Neuroscience Institution
Conditions	Total Hip Arthroplasty (THA), Intrathecal Anesthesia, Hip Osteoarthritis
Enrollment	20 participants
Start Date	2025-04-25
Primary Completion	2025-05-25 (estimated)
Study Completion	2025-05-26 (estimated)
Updated on ClinicalTrials.gov	2025-04-27