Clinical Trial

Immunomodulatory Effects of NB-UVB and Steroids in Vitiligo: A Study on CXCL11 and TEMRA Biomarkers

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Record status
This record was last updated April 27, 2025 (before its estimated December 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
this is a prospective, randomized controlled trial (RCT) investigating the immunological effects of narrowband UVB (NB-UVB) phototherapy-both as monotherapy and in combination with oral mini-pulse (OMP) steroids-in non-segmental vitiligo patients. The study evaluates changes in CXCL11 (a chemokine involved in T-cell recruitment) and TEMRA (terminally differentiated effector memory T cells re-expressing CD45RA) levels in serum before and after treatment.
Trial Details
NCT Number NCT06946069
Lead Sponsor Assiut University
Conditions Vitiligo, NB-UVB
Enrollment 40 participants
Start Date 2025-09-01
Primary Completion 2025-12-30 (estimated)
Study Completion 2026-09-30 (estimated)
Updated on ClinicalTrials.gov 2025-04-27