Pseudoexfoliation and Carpal Tunnel Study

This prospective, single-center case-control study aimed to investigate the association between pseudoexfoliation syndrome (PES) and carpal tunnel syndrome (CTS) using biochemical markers. A total of 159 participants aged 50-80 years were categorized into PES, CTS, and control groups. Diagnoses were confirmed by slit-lamp biomicroscopy for PES and electrophysiological evaluation (EMG) for CTS. Serum biomarkers, including homocysteine, methylmalonic acid, paraoxonase-1 (PON1), homocysteine thiolactonase (HTLase), and matrix metalloproteinases (MMP-2 and MMP-9), were measured. Group comparisons, diagnostic performance (ROC analysis), and independent associations (multinomial logistic regression) were evaluated. Comorbidities were recorded and analyzed in subgroup analyses.

NCT Number	NCT06946030
Lead Sponsor	Ankara Training and Research Hospital
Conditions	Pseudoexfoliation Syndrome, Carpal Tunnel Syndrome (CTS)
Enrollment	159 participants
Start Date	2025-05-01
Primary Completion	2026-01-15 (estimated)
Study Completion	2026-01-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-17