Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP)

The general objective of the proposed project is to characterise phenotypically and functionally ADAMTS13-specific memory B lymphocytes and autoreactive T lymphocytes, in particular follicular helper T lymphocytes, in the acute phase of the disease, but also during its progression after treatment. The aim is to highlight their contribution to the initial pathogenic process, their evolution under treatment, and also their involvement in patients who are refractory to immunosuppressive therapies and during relapses. The aim of this project is to identify early phenotypic or functional parameters that are predictive of relapse and that can be used for personalised optimisation of treatment to maintain remission.

NCT Number	NCT06945861
Lead Sponsor	University Hospital, Rouen
Conditions	Thrombotic Thrombocytopenic Purpura (TTP)
Enrollment	44 participants
Start Date	2023-05-11
Primary Completion	2027-05-10 (estimated)
Study Completion	2028-05-11 (estimated)
Updated on ClinicalTrials.gov	2026-05-04