Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections

This observational study aims to identify the underlying neurobiological and environmental mechanisms that influence vulnerability or resilience to mental illness in the context of infection and their contribution to severe infective outcomes in people with pre-existing mental illness. The main questions it aims to answer are: * How do viral infections influence the development of mental illness? * What neurobiological and environmental factors contribute to influence the development of mental illness following infection? * How do these factors relate to the severity of infectious illness in people with pre-existing mental disorders? Researchers will move from large population databases to well-defined, deeply characterised samples to explore the association between infection and subsequent mental health outcomes, and the biological mechanisms behind these changes. Participants's data has already been collected.

NCT Number	NCT06945627
Lead Sponsor	Sara Poletti
Conditions	Severe Mental Illness, Inflammation, Viral Infections, Mood Disorders, Schizophrenia
Enrollment	408,551 participants
Start Date	2024-05-02
Primary Completion	2026-05 (estimated)
Study Completion	2027-03 (estimated)
Updated on ClinicalTrials.gov	2025-05-14