Comparative Study of Three Collagen Membranes: 1 Non-cross-linked and 2 Cross-linked

This study is being done to compare how quickly three different types of collagen membranes break down when they are exposed to the mouth. These membranes are often used in dental and oral surgery to help with healing and tissue growth. The goal is to find out if one membrane lasts longer than the others, which may help doctors choose the best option for different procedures. In this study, the membranes will be placed in the mouth in a specific area near the gums of the upper back teeth. The study is designed so that neither the patients nor the researchers evaluating the results will know which membrane is which (this is called a double-blind study). Over time, researchers will measure how much each membrane has broken down. This information may help improve treatment planning and patient outcomes in dental care.

NCT Number	NCT06944639
Lead Sponsor	Andrea Ravida Collaborators: Dentsply Sirona Inc.
Conditions	Bone Regeneration
Enrollment	25 participants
Start Date	2025-04-28
Primary Completion	2026-06-25 (estimated)
Study Completion	2026-06-25 (estimated)
Updated on ClinicalTrials.gov	2026-08-06