Clinical Trial

Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery

Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB. Utilizing advanced statistical models (BOIN/BOP2 design), we aim to systematically evaluate the volume-effect relationship of liposomal bupivacaine, providing precise dosing recommendations to advance personalized and optimized analgesic protocols for knee surgery.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-04-17; most recent amendment 2025-08-31.
Trial Details
NCT Number NCT06942689
Lead Sponsor Nanjing First Hospital, Nanjing Medical University
Conditions Optimal Volume of Liposomal Bupivacaine
Enrollment 63 participants
Start Date 2025-06-01
Primary Completion 2027-12-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-09-08