Clinical Trial

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Recruiting Early Phase 1
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Summary
Pilot study to determine feasibility of adding intrathecal chemotherapy and maintenance therapy after high dose chemotherapy for treatment of newly diagnosed HR-EBTs in patients less than 6 years of age.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2025-04-21; most recent amendment 2026-07-13.
Status change: Not Yet Recruiting → Recruiting 2025-12-10
Trial Details
NCT Number NCT06942039
Lead Sponsor C17 Council
Conditions CNS Embryonal Tumor, CNS, Medulloblastoma, Atypical Teratoid Rhabdoid Tumor, Medulloblastoma, Childhood, Medulloblastoma, Group 3, Medulloblastoma, Group 4, Pineoblastoma, Neuroblastoma +6 more
Enrollment 15 participants
Start Date 2025-09-23
Primary Completion 2030-12-31 (estimated)
Study Completion 2032-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-14