Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT06941467 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds

StatusRecruiting
PhasePhase 1
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 9 months later Apr 1, 2026 → Jan 31, 2027
See other at-risk trials from Icahn School of Medicine at Mount Sinai

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary completion pushed from Apr 1, 2026 to Jan 31, 2027
    • Study completion pushed from Apr 1, 2026 to Mar 1, 2027
    • Eligibility criteria expanded, about 21 words
    • Secondary endpoints: details revised at 3 of 4 entries
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Topical timolol, a β2-Adrenergic receptor (B2AR) antagonist, has demonstrated promise in wound healing over the past several years. The majority of the literature has evaluated the use of topical timolol to shorten wound healing time in chronic wounds of non-surgical etiologies. To date, there are no prospective randomized clinical trials evaluating the role of topical timolol for shortening wound healing time in acute open surgical wounds. Therefore, the purpose of this study is to determine whether or not topical timolol solution decreases time to wound healing in patients with defects after Mohs Micrographic Surgery (MMS) that cannot be closed with sutures and are left to heal by second intent. The research team also will look to determine if there is a difference in cosmesis of wounds treated with topical timolol compared to those treated with the standard of care. The present study will primarily focus on wounds in the distal lower extremity as these are most commonly left to heal by secondary intent
Trial Details
NCT Number NCT06941467
Lead Sponsor Icahn School of Medicine at Mount Sinai
Conditions
(from sponsor)		 Wound Healing, Mohs Micrographic Surgery
Enrollment 102 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov