Clinical Trial

Ultrasound Stimulation for Patients in a Disorder of Consciousness

Study acronym: tFUS
Recruiting
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Summary
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a therapeutic to promote recovery in patients with prolonged DoC as compared to sham treatment, (2) establish dose-related safety and efficacy of tFUS as a therapeutic intervention in prolonged DoC patients and (3) explore preliminary predictors and biomarkers of susceptibility and response to thalamic sonication.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-04-14; most recent amendment 2026-05-18.
Status change: Not Yet Recruiting → Recruiting 2025-10-06
Trial Details
NCT Number NCT06939348
Lead Sponsor University of California, Los Angeles
Collaborators: Casa Colina Hospital and Centers for Healthcare, Spaulding Rehabilitation Hospital, Massachusetts General Hospital
Conditions Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Enrollment 60 participants
Start Date 2025-04-26
Primary Completion 2028-03-28 (estimated)
Study Completion 2028-09-29 (estimated)
Updated on ClinicalTrials.gov 2026-05-22