ERAS Protocols in Breast Conserving Surgery

Enhanced Recovery After Surgery (ERAS) protocols have been of increasing interest in the surgical community for decades. The emphasis has been development of protocols to maximize pain control post-operatively without the use of opioids. While this approach has been studied extensively in the oncology surgery literature, little data exists on the utility of ERAS protocols in the setting of breast conserving surgery (BCS), which is a type of surgery to remove breast cancer while saving as much of the breast as possible. The purpose of this study is to determine the utility of implementing ERAS protocols in breast cancer patients undergoing breast conserving surgery. Study participants will be randomized to either ERAS protocol or standard peri-operative care without ERAS. The study will assess the how many opioid prescriptions are given in the first week after surgery and how much pain participants report right after surgery. Investigators will also look at how long participants stay in the recovery room and if medicine for nausea is needed.

NCT Number	NCT06938581
Lead Sponsor	University of Nebraska
Conditions	Breast Cancer, Postoperative Recovery
Enrollment	260 participants
Start Date	2025-07-11
Primary Completion	2029-01 (estimated)
Study Completion	2029-02 (estimated)
Updated on ClinicalTrials.gov	2026-05-19