Clinical Trial

Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management

Recruiting
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Summary
This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodontic treatment. Participants will receive standard preoperative NSAIDs before undergoing root canal therapy, and their pain responses will be assessed. Genetic analysis will be performed to investigate possible associations between drug response and individual gene variations. The study seeks to improve personalized approaches in endodontic pain management.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-04-14; most recent amendment 2025-07-10.
Trial Details
NCT Number NCT06937853
Lead Sponsor Ataturk University
Conditions Postoperative Pain
Enrollment 200 participants
Start Date 2024-05-10
Primary Completion 2025-07-10 (estimated)
Study Completion 2025-08-03 (estimated)
Updated on ClinicalTrials.gov 2025-07-11