Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females

This study is a randomized, double-blind, placebo-controlled trial designed to examine the effects of pre-sleep creatine monohydrate supplementation on anaerobic performance and muscle damage markers in recreationally active females. Participants will be randomly assigned to receive either 5 grams of creatine monohydrate or a placebo 30 minutes before sleep for seven consecutive days. Anaerobic performance will be assessed using the Wingate Anaerobic Test, evaluating peak and average power output and fatigue index. Blood samples will be collected before and after the supplementation period to analyze markers of muscle damage, including creatine kinase and lactate dehydrogenase. This study aims to provide insight into the efficacy of short-term, time-specific creatine supplementation for enhancing performance and recovery.

NCT Number	NCT06937190
Lead Sponsor	Ankara Yildirim Beyazıt University
Conditions	Anaerobic Performance, Sports Nutrition, Exercise Recovery, Muscle Fatigue, Creatine Supplementation, Recreational Physical Activity, Female Athletes
Enrollment	24 participants
Start Date	2025-04-01
Primary Completion	2025-05-10 (estimated)
Study Completion	2025-07-10 (estimated)
Updated on ClinicalTrials.gov	2025-04-22