Herpes Simplex Virus Type 1 Infection/Reactivation of Patients With Severe Pneumonia（the HSV-SP Study）

Severe pneumonia(SP) is a one of the main causes of death for critically ill patients.Samples of bronchoalveolar lavage fluid (BALF) from SP patients often report positive for herpes simplex virus type 1 (HSV-1) DNA. However, to date, it is unclear the impact and significance of this positive result on SP patients. This study will evaluate the prognostic impact of lower respiratory tract HSV-1 infection/reactivation on ICU severe pneumonia patients.At the same time, by analyzing the risk factors that affect prognosis, we will identify populations with the potential for intervention benefits and provide a basis for further intervention treatment.

NCT Number	NCT06936683
Lead Sponsor	Second Affiliated Hospital of Guangzhou Medical University Collaborators: Guangzhou Red Cross Hospital, Guangzhou First People's Hospital, Gongguan People's Hospital, Guangzhou Medical University
Conditions	Severe Pneumonia
Enrollment	323 participants
Start Date	2025-06-01
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-10-01 (estimated)
Updated on ClinicalTrials.gov	2025-04-25