Cognitive Remediation Therapy for Schizophrenia: Effects on EEG and Emotional Regulation

This study aims to determine whether Cognitive Remediation Therapy (CRT) can improve attention, memory, and emotional regulation in people with schizophrenia. CRT is a structured program that includes exercises to strengthen cognitive skills such as problem-solving, working memory, and emotion regulation. The study will recruit 60 participants: 30 individuals with schizophrenia and 30 healthy individuals of similar age and gender. Those with schizophrenia will be randomly assigned to either receive CRT or be placed on a waitlist without therapy. All participants will undergo non-invasive brain activity (EEG) and emotional response (GSR) recordings before and after the therapy. The study's main question is: Does participating in a 12-week CRT program improve brain-based markers of attention and emotional regulation in people with schizophrenia? Additional tests, such as memory and emotion recognition tasks and self-report questionnaires, will help assess changes in thinking skills and emotional well-being. The study may help better understand how CRT affects both brain function and quality of life in schizophrenia.

NCT Number	NCT06936397
Lead Sponsor	Beykoz University Collaborators: Uskudar University, Istanbul Nisantasi University
Conditions	Schizophrenia Disorders, Cognitive Dysfunction, Emotion Regulation Disorders
Enrollment	60 participants
Start Date	2025-03-15
Primary Completion	2025-08-15 (estimated)
Study Completion	2025-10-15 (estimated)
Updated on ClinicalTrials.gov	2025-04-20