Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery

This is a randomized, double-blind clinical trial designed to compare the inotropic effects of vasopressin versus norepinephrine in patients who develop vasoplegic syndrome in the immediate postoperative period following cardiac surgery. Vasoplegic syndrome is characterized by severe hypotension due to systemic vasodilation, despite adequate fluid resuscitation and preserved or elevated cardiac output. Vasopressors are essential in restoring hemodynamic stability in this context; however, their impact on myocardial performance remains uncertain. While norepinephrine is the standard first-line agent, vasopressin has shown potential benefits, including reduced catecholamine exposure and fewer adverse cardiovascular effects. This study aims to assess changes in cardiac output and other echocardiographic and hemodynamic parameters after administration of either vasopressin or norepinephrine. The findings are expected to contribute to optimizing vasopressor selection in vasoplegic patients after cardiac surgery and improving clinical outcomes.

NCT Number	NCT06934798
Lead Sponsor	University of Sao Paulo Collaborators: Hospital Universitário Cassiano Antônio de Moraes/HUCAM, Hospital Santa Casa de Misericórdia de Vitória
Conditions	Vasoplegic Syndrome of Cardiac Surgery
Enrollment	350 participants
Start Date	2024-04-01
Primary Completion	2025-07-30 (estimated)
Study Completion	2025-07-30 (estimated)
Updated on ClinicalTrials.gov	2025-04-30