Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia

Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia. Conclusive evidence for patients with AHRF without COVID-19 is still missing. The investigators hypothesis that awake prone position in patients with AHRF is superior to standard supine/semi-recumbent position in terms of reducing the rate of tracheal intubation and/or all-cause death within 28 days after randomization.

NCT Number	NCT06931938
Lead Sponsor	Universitätsklinikum Hamburg-Eppendorf Collaborators: Charite University, Berlin, Germany, Asklepios Kliniken Hamburg GmbH, University Hospital Tuebingen, University Hospital Heidelberg, Klinikum Würzburg Mitte gGmbH, Missioklinik, Elisabeth-Krankenhaus Essen, Hannover Medical School, Universitätsklinikum Freiburg, Krankenhaus Barmherzige Brüder, Regensburg, Technical University of Munich, Klinikum Nürnberg, RWTH Aachen University, Lung Clinic Hemer, University of Leipzig, Wuerzburg University Hospital, University Hospital Erlangen, University Hospital Schleswig-Holstein, Klinikum Hanover-Siloah Hospital, Ludwig-Maximilians - University of Munich, Bielefeld University
Conditions	Acute Hypoxemic Respiratory Failure
Enrollment	342 participants
Start Date	2025-04-11
Primary Completion	2026-12-30 (estimated)
Study Completion	2027-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-04