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Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia

Study acronym: PROSA
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

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  1. Site details revised
    • Collaborators: 3 to 20
    v4
  2. Collaborators: 1 to 3v3
  3. Start date changed from estimate of Apr 8, 2025 to Apr 11, 2025
    • Study description expanded, about 2 words
    • Collaborators expanded, about 4 words
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia. Conclusive evidence for patients with AHRF without COVID-19 is still missing. The investigators hypothesis that awake prone position in patients with AHRF is superior to standard supine/semi-recumbent position in terms of reducing the rate of tracheal intubation and/or all-cause death within 28 days after randomization.
Trial Details
NCT Number NCT06931938
Lead Sponsor Universitätsklinikum Hamburg-Eppendorf
Collaborators: Charite University, Berlin, Germany, Asklepios Kliniken Hamburg GmbH, University Hospital Tuebingen, University Hospital Heidelberg, Klinikum Würzburg Mitte gGmbH, Missioklinik, Elisabeth-Krankenhaus Essen, Hannover Medical School, Universitätsklinikum Freiburg, Krankenhaus Barmherzige Brüder, Regensburg, Technical University of Munich, Klinikum Nürnberg, RWTH Aachen University, Lung Clinic Hemer, University of Leipzig, Wuerzburg University Hospital, University Hospital Erlangen, University Hospital Schleswig-Holstein, Klinikum Hanover-Siloah Hospital, Ludwig-Maximilians - University of Munich, Bielefeld University
Conditions
(from sponsor)		 Acute Hypoxemic Respiratory Failure
Related terms Respiratory Insufficiency
Enrollment 342 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov