Neoadjuvant Radiochemotherapy Combined With QL1706 for Low Rectal Cancer

This study investigates the efficacy of neoadjuvant radiotherapy combined with QL1706 in MSS-type low-grade rectal cancer. This study is a prospective multicohort study, with cohort 1 intended to include patients with low grade early rectal cancer (cT1-3N0M0) and cohort 2 intended to include patients with low grade locally advanced rectal cancer (cT4N0M0 or cTanyN+M0). Each cohort included 30 subjects receiving neoadjuvant radiotherapy combined with QL1706 treatment.

NCT Number	NCT06931873
Lead Sponsor	Changhai Hospital
Conditions	Rectal Cancer
Enrollment	60 participants
Start Date	2025-05-20
Primary Completion	2028-03-01 (estimated)
Study Completion	2035-03-01 (estimated)
Updated on ClinicalTrials.gov	2025-04-17