Staging Heart Failure With Preserved Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) is considered a systemic condition in which the prevalence of cardiovascular, metabolic, pulmonary and renal conditions determine the extent of cardiac involvement. Numerous attempts have been made to phenotype HFpEF, but patients still lack a clinically and/or prognostically relevant approach. Progressive cardiac deterioration in HFpEF appears to be associated with a worse prognosis. However, no attempt has been made to classify the extent of cardiac involvement in HFpEF. Investigators proposed the concept of HFpEF staging according to the extent of cardiac involvement identified by transthoracic echocardiography: Stage 1: isolated left ventricular involvement; Stage 2: left atrial myopathy; Stage 3: pulmonary vasculature involvement; and Stage 4: right chambers involvement. The study aims to investigate the associations between the proposed stages and clinical outcomes in HFpEF patients.

NCT Number	NCT06931015
Lead Sponsor	I.M. Sechenov First Moscow State Medical University
Conditions	Heart Failure With Preserved Ejection Fraction, Cardiovascular Diseases, Heart Failure
Enrollment	700 participants
Start Date	2025-04-20
Primary Completion	2028-04-13 (estimated)
Study Completion	2028-12-13 (estimated)
Updated on ClinicalTrials.gov	2025-04-20