Multi-center Randomized Controlled Clinical Study of Shenling Baishu Granule to Prevent the Recurrence of Low-risk Colorectal Adenoma

1. Complete a large-sample, multicenter, randomized blank-controlled clinical trial to evaluate Shenling Baizhu Granules for the prevention of colorectal adenoma recurrence. 2. Generate high-level, internationally recognized clinical evidence to support the development of clinical practice guidelines for the prevention and treatment of colorectal adenoma using traditional Chinese medicine, and to strengthen the recommendation level of Shenling Baizhu Granules in clinical guidelines. 3. Define the clinical characteristics of patient subgroups most likely to benefit from Shenling Baizhu Granules for preventing colorectal adenoma recurrence.

NCT Number	NCT06930157
Lead Sponsor	Shanghai Jiao Tong University School of Medicine Collaborators: Affiliated Hospital of Nanjing University of Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Sixth Affiliated Hospital, Sun Yat-sen University, Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, Beijing Friendship Hospital, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Institute of Science, Beijing Tongrentang Co., Ltd.
Conditions	Low-risk Colorectal Adenoma
Enrollment	624 participants
Start Date	2025-11-24
Primary Completion	2028-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-28