Clinical Trial

Antidepressant Response of DMT Masked With Propofol

Study acronym: DMT4D
Recruiting
View on ClinicalTrials.gov →
Summary
The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic experience.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-04-11; most recent amendment 2026-03-27.
Status change: Not Yet Recruiting → Recruiting 2025-08-07
Trial Details
NCT Number NCT06927076
Lead Sponsor University Hospital, Basel, Switzerland
Conditions Major Depressive Disorder, Psychedelic Experiences
Enrollment 112 participants
Start Date 2025-08-05
Primary Completion 2029-03 (estimated)
Study Completion 2029-03 (estimated)
Updated on ClinicalTrials.gov 2026-04-02