Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty

Double-blind randomized placebo-controlled clinical trial with two parallel arms. The main objective is to evaluate the efficacy and safety of creatine supplementation in older adults who have been operated on for total knee arthroplasty and undergoing a usual rehabilitation program. The intervention will consist of daily creatine monohydrate supplementation for 12 weeks. The intervention will start after surgery with a loading dose of 20g/day for 1 week and then continue with a maintenance dose of 5g/day for 11 weeks. Main outcome mesures included muscle mass, muscle strenght, sarcopenia, frailty, functional capacity and physical performance and will be assessed at baseline, 3 and 6 months follow-up.

NCT Number	NCT06925880
Lead Sponsor	Consorci Sanitari del Maresme Collaborators: Fundació Privada Salut del Consorci Sanitari del Maresme
Conditions	Sarcopenia in Elderly, Frailty at Older Adults, Functional Capacity, Creatine Supplementation, Arthroplasties, Knee Replacement, Physical Performance
Enrollment	262 participants
Start Date	2025-06-10
Primary Completion	2027-05-31 (estimated)
Study Completion	2027-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-30