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CD7 CAR T-Cell Therapy for r/r T-cell Lymphomas

StatusRecruiting
PhasePhase 1/2
Started2025-04-01
View on ClinicalTrials.gov ↗
Record status
This record was last updated May 13, 2025 (before its estimated April 1, 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2025-05-11
minor
Study Status, Contacts/Locations v1
Study sites3→4
2025-04-06
minor
Original filing
This is a multi-center, open-label, non-randomized, single-arm clinical trial. Refractory/relapse T-NHL patients are treated with autologous and allogeneic CD7 CAR T-cell therapy. The primary objective is to prospectively evaluate the safety of CD7 CAR T cell bridging to HSCT in the treatment of r/r T-NHL. The primary endpoint is the type and incidence of dose limiting toxicity (DLT) within 21 days after CD7 CAR-T cell infusion. A total of 36 subjects is estimated to be enrolled.
Trial Details
NCT Number NCT06925464
Lead Sponsor Beijing GoBroad Hospital
Collaborators: Ruijin Hospital, Shanghai Liquan Hospital
Conditions T-Cell Non-Hodgkin Lymphoma, T-cell Lymphoma (PTCL and CTCL)
Enrollment 36 participants
Start Date 2025-04-01
Primary Completion 2026-04-01 (estimated)
Study Completion 2027-04-01 (estimated)
Updated on ClinicalTrials.gov 2025-05-13