Clinical Trial

The Children's Adaptive Deep Brain Stimulation for Epilepsy Trial

Study acronym: CADET
Recruiting
View on ClinicalTrials.gov →
Summary
The CADET Trial will investigate the effectiveness of deep brain stimulation (DBS) to reduce the frequency of seizures in children with Lennox-Gastaut syndrome (LGS). The CADET Trial will use a non-CE/UKCA marked device - the Picostim DBS system. The SMART-DBS study is a sub-study of the CADET Trial. SMART-DBS will investigate the application of adaptive DBS for the treatment of children with LGS. Children will be recruited after they exit from either the prior 'CADET Pilot Study' or 'CADET Trial' - meaning that these children will already be receiving therapy with an already implanted Picostim device.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-04-04; most recent amendment 2026-04-01.
Status change: Not Yet Recruiting → Recruiting 2026-04-01
Trial Details
NCT Number NCT06924086
Lead Sponsor University College, London
Collaborators: Great Ormond Street Hospital for Children NHS Foundation Trust, King's College Hospital NHS Trust, University of Oxford, King's College London
Conditions Lennox Gastaut Syndrome (LGS)
Enrollment 22 participants
Start Date 2026-03-24
Primary Completion 2028-01-31 (estimated)
Study Completion 2028-01-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-07