Clinical Trial

Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study

Study acronym: PILDI
Recruiting Phase 2
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Summary
There are very few data in the literature on changes in inflammatory markers when lidocaine is administered perioperatively in patients with colorectal cancer. In patients undergoing surgery for colon cancer, the aim is to conduct a double-blind placebo-controlled study to determine differences in levels of pro-inflammatory markers, postoperative pain and opioid analgesic consumption in the first two days after surgery, and the time to first postoperative bowel movement. Groups of patients receiving perioperative lidocaine infusion, high dose dexamethasone or placebo will be compared.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-04-04.
Status change: Not Yet Recruiting → Recruiting 2026-02-03
Trial Details
NCT Number NCT06923787
Lead Sponsor Institute of Oncology Ljubljana
Conditions Colon Cancer
Enrollment 100 participants
Start Date 2026-02-03
Primary Completion 2027-07-01 (estimated)
Study Completion 2028-07-01 (estimated)
Updated on ClinicalTrials.gov 2026-02-05