Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption

Acetaminophen (Tylenol) is a commonly used medication after surgery to control pain. Tablets for oral use and suppositories for rectal use are the most frequently employed forms of acetaminophen after surgery. Intravenous (IV) acetaminophen is widely used in several countries but is not a standard medication for the adult population in Canada. It is mainly considered when it is impossible to take medication in tablet or suppository form. Opioids (Morphine, Hydromorphone, Oxycodone, etc.) are another class of medications commonly used after surgery for pain management. While they are generally very effective and stronger than acetaminophen or other pain relievers (e.g., ibuprofen/Advil), reducing their use is preferable, as they can cause various side effects such as nausea, dizziness, and dependence. IV acetaminophen may help control pain while also reducing opioid consumption. However, there are few high-quality scientific studies proving the benefits of IV acetaminophen compared to other forms, such as tablets or suppositories. Acetaminophen has been available in Canada for many years and has already been recommended for use in Quebec by the Institut national d'excellence en santé et services sociaux (INESSS) under certain conditions. This study aims to validate its benefits with clear data.

NCT Number	NCT06923540
Lead Sponsor	Centre hospitalier de l'Université de Montréal (CHUM)
Conditions	Post Operative Analgesia, Opioid Consumption, Postoperative, Acetaminophen, Abdominal Surgeries, Post Operative Bowel Dysfunction, Post Operative Nausea and Vomiting, Post Operative Pain Control, Mobility +3 more
Enrollment	140 participants
Start Date	2025-04-28
Primary Completion	2025-08-15 (estimated)
Study Completion	2025-08-15 (estimated)
Updated on ClinicalTrials.gov	2025-04-11