The Effect of Exercise on Metabolic Alteration

The goal of this clinical trial is to study the effectiveness of aerobic exercise in treating obesity in adults and to assess the efficacy of exercise. The primary research questions it seeks to address are as follows: * To what extent does exercise increase the total energy expenditure of participants? * Why and how does the energy expenditure from exercise not fully compensate for the total energy expenditure (TEE)? * Researchers will assess the efficacy and potential challenges of using exercise as a treatment for obesity by comparing the measurement data before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20). Participants will engage in the following activities: * Engage in running sessions supervised five times a week for a duration of 12 weeks. * Attend laboratory sessions both before and after the exercise intervention period for metabolic and anthropometric measurements, as well as sample collection. * Return to the laboratory for further metabolic and anthropometric measurements and sample collection8 weeks post-completion of exercise intervention.

NCT Number	NCT06923163
Lead Sponsor	Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Conditions	Sedentary Behavior, Healthy Participants, Adult
Enrollment	80 participants
Start Date	2025-05-01
Primary Completion	2026-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-01-21