Hemadsorption to Enhance Drug Elimination in Intoxications

In this trial the investigators assess the effectiveness of applying a hemadsorber (cytosorb®) in removing benzodiazepines or tricyclic antidepressants in intoxicated patients admitted to ICU with prolonged impaired consciousness. This is a one arm interventional investigation where a hemadsorption filter is applied in patients fulfilling inclusion criteria 8 hours after admission. Plasma titer of the neurodepressing drug will be collected sequentially both before and after start of hemadsorption to evaluate the speed of drug elimination before and after application of a hemadsorption filter. Pre- and post filter titers will be obtained to evaluate adsorbability and to evaluate time to saturation of the filter.

NCT Number	NCT06922786
Lead Sponsor	Universitair Ziekenhuis Brussel
Conditions	Intoxication by Drug
Enrollment	18 participants
Start Date	2025-05
Primary Completion	2028-12 (estimated)
Study Completion	2029-01 (estimated)
Updated on ClinicalTrials.gov	2025-05-15