Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes

EBUS-guided cryobiopsy of mediastinal and hilar lymph nodes has shown to be a useful diagnostic tool to obtain tissue for histological analysis and further targeted therapies in lung malignancies. Due to the large size and better quality of the tissue samples, a higher diagnostic yield than with transbronchial needle aspiration (TBNA) can be expected, especially in non-solid tumors. In previous studies different biopsy protocols were used. The freezing time of cryoprobe (which defines the sample sizes) ranged from 3 to 7 s and the number of biopsies was between 1 and 4 samples. It is therefore unclear what freezing times and biopsy frequency are required to obtain the best histological information.

NCT Number	NCT06921681
Lead Sponsor	University of Zurich Collaborators: Aarau Cantonal Hospital (KSA), Waid City Hospital, Zurich, Kantonsspital Winterthur KSW, Unispital Basel, Spital Uster AG, Uster, Switzerland, Clinique des Grangettes, Chêne-Bougeries, Insel Gruppe AG, University Hospital Bern, Réseau Hospitalier Neuchâtelois, University of Lausanne Hospitals, Cantonal Hospital of St. Gallen, Ospedale Regionale Bellinzona e Valli, HUG - Hôpitaux universitaires de Genève, Kantonsspital Chur, Switzerland, Hôpital du Valais
Conditions	Lung Cancer (NSCLC)
Enrollment	136 participants
Start Date	2025-03-07
Primary Completion	2029-04-01 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-04-10