Clinical Trial

Psilocybin With Intracranial Neural Sensing

Study acronym: PINS
Enrolling by Invitation Phase 1
View on ClinicalTrials.gov →
Summary
This is an open-label, single-arm, pilot study exploring the neural, sensory, and cognitive effects of a single, medium dose of psilocybin in patients with chronic pain who already have implanted sensing-capable deep brain stimulation (DBS) devices. Outcomes include multi-site neural recording from previously placed ambulatory sensing-capable DBS devices, quantitative sensory and cognitive testing, and self-reports of pain. We hypothesize that psilocybin will change functional connectivity, decrease clinical and task-based pain reports, and improve cognitive functions.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-04-02.
Status change: Not Yet Recruiting → Enrolling by Invitation 2025-06-05
Trial Details
NCT Number NCT06919640
Lead Sponsor Joshua Woolley, MD, PhD
Conditions Chronic Pain
Enrollment 20 participants
Start Date 2025-06-01
Primary Completion 2028-04-30 (estimated)
Study Completion 2028-04-30 (estimated)
Updated on ClinicalTrials.gov 2025-06-06