Negative HPV Test Results on Infinity/GeneXpert® With the Presence of a Late Amplification Signal: What Does This Mean ? (PaPCR)

The aim of this retrospective, single-center, observational study is to improve the diagnosis and interpretation of cervical cancer by better detection of epithelial lesions in the case of a late HPV PCR amplification signal rendered negative by routine laboratory testing using GeneXpert® technology. The various evaluation criteria are : * Presence or absence of lesions on cytological control following a negative HPV test with a late amplification signal on cervico-uterine and anal smear samples from patients seen in consultation at Brest University Hospital from 01/01/2022 to 30/06/2024 (after conventional PCR and genotyping). * Comparison of the GeneXpert® technique with the results of another conventional pan-genotypic Papillomavirus PCR test.

NCT Number	NCT06919627
Lead Sponsor	University Hospital, Brest
Conditions	Cervical Cancers, Papillomavirus Infections, Papillomavirus Type 16/18 Infection
Enrollment	45 participants
Start Date	2025-03-27
Primary Completion	2025-04-14 (estimated)
Study Completion	2026-01-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-02