Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis

Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity. Diaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed to improve lung function by correcting diaphragmatic elevation. While its benefits have been reported in retrospective reports, prospective studies are lacking. This prospective observational cohort study aimsto evaluate the short- and long-term effects of robot-assisted diaphragmatic plication on subjective breathlessness, physical performance, lung function, blood gases, and imaging findings at five Swedish university hospitals: Gothenburg, Linköping, Lund, Umeå, and Uppsala. Patients will be assessed preoperatively and postoperatively after one to three months and after one and three years.

NCT Number	NCT06919185
Lead Sponsor	Uppsala County Council, Sweden Collaborators: Uppsala University
Conditions	Diaphragmatic Plication, Diaphragmatic Paralysis, Diaphragmatic Eventration
Enrollment	50 participants
Start Date	2025-05
Primary Completion	2031-12 (estimated)
Study Completion	2031-12 (estimated)
Updated on ClinicalTrials.gov	2025-04-11