Quality of Life During Different Regimens of Combined Hormonal Contraceptives in Women of Reproductive Age

The aim of the present study is to investigate the psychosexual effects of combined hormonal contraception regimens, comparing them in terms of estrogen type and dosage, hormonal combination regimen and different routes of administration, in women seeking a hormonal contraception method to prevent unwanted pregnancies. In particular, the study focuses on the incidence of mood disorders and sexual dysfunctions associated with distress in the entire study population using combined hormonal contraception. It will also examine the incidence of these conditions under the influence of specific combined hormonal contraceptives, as well as whether different types of progestins and the route of administration (oral, vaginal or transdermal) may affect the occurrence of mood disorders and sexual dysfunctions.

NCT Number	NCT06918873
Lead Sponsor	Fondazione IRCCS Policlinico San Matteo di Pavia
Conditions	Hormonal Contraception
Enrollment	400 participants
Start Date	2014-05-05
Primary Completion	2026-01 (estimated)
Study Completion	2026-01 (estimated)
Updated on ClinicalTrials.gov	2025-04-09