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Lipid Infusions to Optimize Nutrition Trial

Study acronym: LION
StatusRecruiting
PhasePhase 2
Started2026-04-29
View on ClinicalTrials.gov ↗

Amendment history

2026-08-03
Study Status, Contacts/Locations v6
Start date2026-04-01→2026-04-29
Study sitescontacts updated at 1 of 1 site
2026-07-09
Study Status, Contacts/Locations v5
Start dateestimated 2026-05-01→confirmed 2026-04-01
Study sitescontacts updated at 1 of 1 site
2026-04-29
Study Status, Contacts/Locations v4
Recruitment opened
Study sitesdetails revised at 1 of 1 site
2026-04-14
Study Identification, Study Status, Contacts/Locations v3
Start date2026-03-01→2026-05-01
Study sitescontacts updated at 1 of 1 site
2025-12-08
Study Status, Study Design, Eligibility, Contacts/Locations v2
Study sitescontacts updated at 1 of 1 site
2025-11-14
Study Status, Contacts/Locations v1
Start date2025-07-01→2026-03-01
Study sitescontacts updated at 1 of 1 site
2025-04-03
Original filing
The purpose of this study is to identify survival free of bronchopulmonary dysplasia (BPD), fatty acid profiles, and early biochemical measures for oxidative stress comparing mixed oil lipid emulsion (MOLE) vs soybean oil-based lipid emulsion (SOLE) and to establish whether MOLE or SOLE is more effective in minimizing pulmonary outcomes, neonatal morbidities, long-term morbidity and mortality, and improving discharge growth and Bayley Scales of Infant Development Fourth Edition (BSID-IV) neurodevelopmental assessment at two years
Trial Details
NCT Number NCT06915441
Lead Sponsor The University of Texas Health Science Center, Houston
Conditions Bronchopulmonary Dysplasia, Neurodevelopmental Impairment
Enrollment 230 participants
Start Date 2026-04-29
Primary Completion 2028-07-30 (estimated)
Study Completion 2030-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-06