Clinical Trial

ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the Oropharynx

Recruiting
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Summary
This study is a prospective phase II trial, designed to assess the efficacy and feasibility of adjuvant treatment deintensification guided by ctHPVDNA levels for patients with HPV+OPSCC who undergo transoral surgery and neck dissection.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-04-01; most recent amendment 2025-07-28.
Status change: Not Yet Recruiting → Recruiting 2025-06-18
Trial Details
NCT Number NCT06915038
Lead Sponsor Indiana University
Conditions Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer, Throat Cancer, Tonsil Cancer
Enrollment 120 participants
Start Date 2025-06-11
Primary Completion 2028-12 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2026-08-11