Real-time Smoking Cessation Instant Messaging Support Using a Large Language Model (LLM)-Based Chatbot Via "Quit to Win" 2025 (QTW2025)

The goal of this trial is to learn if chatbot-based instant messaging works to help smoking cessation in general adult smokers. It will also learn about the experience, attitude, and perception of using an LLM-based chatbot. The main questions it aims to answer are: 1. Will LLM-based chatbot smoking cessation intervention have a higher validated abstinence rate than the control group? 2. Will LLM-based chatbot smoking cessation intervention have a higher self-reported abstinence rate, smoking reduction rate, and smoking cessation services use rate than the control group? Researchers will compare LLM-based chatbot smoking cessation intervention to a usual care group (brief advice based on AWARD and personalized active referral) to see if chatbot-based instant messaging support works to promote smoking cessation. Participants in the intervention group will receive: 1. AWARD advice 2. Personalized active referral 3. 12 weeks of chatbot-based instant messaging support (via WhatsApp)

NCT Number	NCT06914492
Lead Sponsor	The University of Hong Kong
Conditions	Smoking Cessation
Enrollment	1,058 participants
Start Date	2025-06-21
Primary Completion	2026-05-31 (estimated)
Study Completion	2026-06-05 (estimated)
Updated on ClinicalTrials.gov	2026-06-10