FET in Adenomyosis

Purpose of the Study: To compare the effectiveness of GnRH agonist downregulation alone versus GnRH agonist combined with letrozole in improving pregnancy outcomes in women with adenomyosis undergoing frozen embryo transfer (FET). Research Question: Is the combined use of GnRH agonist and letrozole more effective than GnRH agonist downregulation alone in achieving better ongoing pregnancy rates in adenomyosis cases undergoing FET? Hypothesis: Null Hypothesis (H₀): The combined use of GnRH agonist and letrozole is not more effective than GnRH agonist downregulation alone in achieving a higher ongoing pregnancy rate in adenomyosis cases undergoing FET. Study Outcomes: Primary Outcome: Ongoing pregnancy rate at 12 weeks of gestation.

NCT Number	NCT06913075
Lead Sponsor	Indira IVF Hospital Pvt Ltd
Conditions	Adenomyosis
Enrollment	700 participants
Start Date	2026-06-25
Primary Completion	2026-07-15 (estimated)
Study Completion	2026-12-23 (estimated)
Updated on ClinicalTrials.gov	2026-01-26