Feasibility Study to Compare Two Ventilatory Modes for Mechanical Ventilation Weaning

We hypothesize that the ventilatory mode Bilevel Positive Airway Pressure without any synchronization (BIPAPasynchro) may facilitate the weaning process of patients intubated with acute hypoxiemic respiratory failure (AHRF) by obviating the problem of patient-ventilator asynchrony. In order to prove this hypothesis a large randomized controlled study should be perfromed comparing BIPAPasynchro versus pressure support ventilation (PSV), the most widely used ventilatory mode during the weaning process. In order to do so, a feasibility trial to demonstrate the ICU personnel can effectively use a non-standard ventilatory mode should be first performed. The objective of our study is, thus, to demonstrate the feasibility of using BIPAasynchro in the Lausanne Adult ICU.

NCT Number	NCT06912906
Lead Sponsor	University of Lausanne Hospitals
Conditions	Mechanical Ventilation Weaning
Enrollment	84 participants
Start Date	2025-09-01
Primary Completion	2027-04-15 (estimated)
Study Completion	2027-04-15 (estimated)
Updated on ClinicalTrials.gov	2025-04-15