Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）

This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction between the internal brain regions of Papez circuit and the function of the external neural network, a prediction model of the characteristic changes of Papez circuit neural network was constructed based on machine learning technology.

NCT Number	NCT06912321
Lead Sponsor	Nanjing First Hospital, Nanjing Medical University
Conditions	Type 2 Diabetes, Insulin Resistance, Cognitive Impairment
Enrollment	400 participants
Start Date	2024-05-01
Primary Completion	2030-05-01 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-04-04