Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome

Meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies. Deep brain stimulation (DBS), initially developed to treat essential tremor and Parkinson's disease, has been explored in recent years as a potential treatment for various dystonias, including Meige's syndrome. This clinical study aims to evaluate the safety and efficacy of bilateral single-electrode ventralis oralis (VO) nucleus stimulation combined with subthalamic nucleus deep brain stimulation (STN-DBS) in patients with Meige syndrome.

NCT Number	NCT06912282
Lead Sponsor	Huashan Hospital
Conditions	Meige Syndrome
Enrollment	20 participants
Start Date	2025-03-06
Primary Completion	2026-06-30 (estimated)
Study Completion	2027-01-01 (estimated)
Updated on ClinicalTrials.gov	2025-04-04