Clinical Trial

Liver Transplantation for Locally Advanced Intrahepatic Cholangiocarcinoma After SIRT and Chemotherapy

Study acronym: RIS-TH
Recruiting
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Summary
The study hypothesis is that liver transplantation after selective internal radiation therapy (SIRT) and chemotherapy would improve 3-year overall survival in patients with locally advanced (unresectable but non-metastatic) intrahepatic cholangiocarcinoma. It is planned to include 36 patients with locally advanced intrahepatic cholangiocarcinoma, not eligible for initial surgery and without metastases. Participants will be recruited from care facilities in France.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-03-28.
Status change: Not Yet Recruiting → Recruiting 2026-04-02
Trial Details
NCT Number NCT06910722
Lead Sponsor Assistance Publique - Hôpitaux de Paris
Conditions Intrahepatic Cholangiocarcinoma, Locally Advanced Intrahepatic Cholangiocarcinoma
Enrollment 36 participants
Start Date 2025-08-28
Primary Completion 2028-08-28 (estimated)
Study Completion 2034-10-01 (estimated)
Updated on ClinicalTrials.gov 2026-04-06