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Optimizing the Care Pathway of Febrile Children Via Capillary C-reactive Protein Assay in Primary Care

Study acronym: CRP-CAP
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Notable Primary and study completion dates: Mar 2026 to Jun 2027 Study sites: 16 to 37v4 Show 1 more changeShow less
    • Study sites: 16 to 37
  2. Minor Eligibility criteria revisedv3 See this version in full on ClinicalTrials.gov ↗
  3. Notable Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Sep 2025 to Sep 15, 2025 · Site details revised at 16 of 16 sitesv2 Show 2 more changesShow less
    • Start date changed from estimate of Sep 2025 to Sep 15, 2025
    • Site details revised at 16 of 16 sites
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Fever is the leading reason for outpatient consultations among children aged 2 to 9 years. The main concern in fever is severe bacterial infection, particularly for younger children. History and clinical examination do not always differentiate viral infections from bacterial infection. In 20% of febrile children, no infectious focus is found after examination and additional tests are necessary. The first one is measuring C-reactive protein (CRP). The results are obtained in several hours on an outpatient basis, causing long delays before starting treatment and often requiring telephone calls or further consultations. Emergency room use is constantly increasing, generating growing tensions within healthcare facilities, yet a large number of visits are avoidable. Among children visiting the pediatric emergency room, parents reported being referred by their primary care physician in approximately 20% of cases for children aged 1 to 5 years and in 30% of cases for children under one year old. The use of capillary medical device to measure CRP in primary care could reduce this referral rate and help relieve overcrowding in emergency rooms, as well as unscheduled consultation centers and medical analysis laboratories. This would result in a streamlined care pathway, saving time for both physicians and patients, as well as reducing the cost of care for the healthcare system.
Trial Details
NCT Number NCT06910631
Lead Sponsor Centre Hospitalier Universitaire de Nīmes
Conditions Fever
Enrollment 420 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov