Oxygenated Gel Therapy in the Management of Oral Aphthous Ulcers

Interventions of both groups: Oxygenated gel Group: 15 patients who used oxygenated gel (Blue®m, Wijhe, Netherlands) were trained by the co-investigator (A.H) through real demonstration for topical application of the gel on aphthous ulcers, which entails the application of 1-2 ml of oxygenated gel directly to the ulcer two times per day and this was repeated for 7 days. Triamcinolone acetonide Group: 15 patients were treated with Kenalog in orabase (Triamcinolone acetonide 0.1% oral paste 5g), four times (i.e., at 8 am, 12 noon, 4 pm, and 8 pm) a day for 7 days at intervention group. Patients in both groups were reexamined after treatment at different intervals (day 3, day 5, day 7, and day 10).

NCT Number	NCT06910579
Lead Sponsor	British University In Egypt
Conditions	Aphthus Ulcer
Enrollment	30 participants
Start Date	2025-03-15
Primary Completion	2026-01-30 (estimated)
Study Completion	2026-04-12 (estimated)
Updated on ClinicalTrials.gov	2025-09-18