Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs

Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.

NCT Number	NCT06910241
Lead Sponsor	Florida Atlantic University Collaborators: Baptist Health South Florida
Conditions	Laceration of Skin
Enrollment	100 participants
Start Date	2025-09-03
Primary Completion	2027-06-30 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-01-07