Clinical Trial

Accelerated Partial Breast Irradiation Using External Beam Volumetric Modulated Arc Therapy (VMAT): a Randomised Non-inferiority Trial of 30 Gy Versus 26 Gy in Five Fractions Investigating Patient-reported Outcomes

Study acronym: PUMA
Not Yet Recruiting
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Summary
For women undergoing radiotherapy following surgery for early-stage breast cancer, breast-related quality of life (BrQoL) is an important consideration. Treating only the part of the breast by radiation where the cancer has been surgically removed (partial breast irradiation or "PBI") rather than the whole breast (whole breast irradiation) can reduce the toxic effects of radiotherapy. This trial aims to evaluate whether there is a difference in patient-reported BrQoL between two total doses of radiation given in five treatments using PBI. If BrQOL for the higher dose of PBI is no worse than the lower dose, using the higher dose would be advised as best practice, given that it is more likely to be more effective in reducing the chance of cancer coming back in the breast than the lower dose.
Trial Details
NCT Number NCT06909032
Lead Sponsor Integrated Community Oncology Network
Collaborators: Icon Cancer Foundation
Conditions Breast Cancer
Enrollment 168 participants
Start Date 2025-04
Primary Completion 2030-07 (estimated)
Study Completion 2032-12 (estimated)
Updated on ClinicalTrials.gov 2025-04-03