Clinical Trial

Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their Complications

Study acronym: Caution

Recruiting

Record status

This record was last updated April 3, 2025 (before its estimated December 31, 2025 completion). Its status may not reflect the trial's current state.

Summary

Study design A retrospective cohort study will be conducted to compare the efficacy and safety of citrate anticoagulation in CRRT among patients with liver failure/dysfunction and severe shock. Objectives 1. Primary Objective: To determine if the etiology of liver failure impacts the incidence of citrate-related complications in patients undergoing CRRT. 2. Secondary Objectives: To compare the efficacy of citrate anticoagulation in terms of renal recovery, filter lifespan, and patient survival between those with liver failure/dysfunction and severe shock.

Trial Details

NCT Number	NCT06908746
Lead Sponsor	University Hospital, Antwerp
Conditions	Liver Failure, AKI - Acute Kidney Injury
Enrollment	100 participants
Start Date	2024-09-30
Primary Completion	2025-12-31 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-04-03